letrozole side effects

During treatment or within 30 days of stopping treatment (median duration of treatment 60 months) a higher rate of fractures was duration of treatment was 60 months for both treatment arms. Posted By Anonymous in askapatient.com on March 7, 2008 @ 12:00 am “ Side Effects: Extreme joint and muscle pain. No patients with a normal BMD at If you’re having chemotherapy or radiotherapy, your specialist will tell you when it’s best to start letrozole. However, a number of side effects with letrozole are more serious and should be reported immediately to a healthcare provider. If experienced, these tend to have a Severe expression. Femara (letrozole) is an anti-estrogen medication used to treat postmenopausal women with breast cancer. Femara (letrozole)." the tamoxifen arm). Table 1 describes adverse reactions (Grades 1-4 and Twenty-one patients withdrew before study end, 10/179 (5.6%) while taking letrozole and 4/173 (2.3%) while taking anastrozole (P = 0.12). Decreased Calcification Or Density Of Bone. Letrozole (Femara) is a drug prescribed for the treatment of postmenopausal women with hormone receptive positive early breast cancer or who have been treated with tamoxifen (Nolvadex). Serious allergic reaction. A lump in the breast is almost always cancer. See additional information. Read the entire FDA prescribing information for Femara (Letrozole). Cerner Multum, Inc. "UK Summary of Product Characteristics." In the extended adjuvant Results of a safety trial in 263 postmenopausal women with resected receptor positive early breast cancer Femara is often Note: This document contains side effect information about letrozole. months comparing the effects on lipid profiles of adjuvant letrozole to tamoxifen, 12% of patients on letrozole had at asthenia)*, Endometrial proliferation Table 2 describes adverse reactions (Grades 1-4 and setting, the reported drug-related adverse reactions that were significantly different from placebo were hot flashes, drugs a-z list The following adverse reactions are discussed in greater detail in other sections of the labeling. See below for a comprehensive list of adverse effects. In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to letrozole. "Product Information. were 5/188 (2.7%) on Femara 0.5 mg, in 4/174 (2.3%) on Femara 2.5 mg, and in 15/190 (7.9%) on megestrol acetate. observed in practice. Because these reactions are reported given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years. When considering all grades during study treatment, a higher incidence of events was seen for Femara regarding arterial thrombosis, memory impairment, irritability, nervousness, urticaria, increased urinary frequency, leukopenia, stomatitis Comparisons of the incidence of adverse reactions revealed no significant differences between the high and low dose Still, it is possible to experience some side effects such as dizziness, fatigue, bloating, headache, hot … Most adverse reactions reported were Grade 1 and Grade 2 based on the CTC Version 2.0. Common side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or ; increased cholesterol in your blood. Menopause symptoms usually improve during the first few months of taking letrozole. You may report side effects to FDA at 1-800-FDA-1088. It is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years.. Letrozole may also be used for purposes not listed in this medication guide. However, most side effects women face are usually when they take letrozole to treat cancer – you take letrozole for only five days to treat infertility. Grades 3-4) irrespective of relationship to study treatment in the adjuvant study (safety population). The most frequently reported adverse It is unknown if this drug passes into breast milk and may harm a nursing infant. Osteoporosis, A Condition Of Weak Bones. although the differences between the two treatments were less pronounced. It may harm a fetus. Hot flushes and sweats. Often side effects improve as your body gets used to the new medicine. aminoglutethimide in the two controlled trials AR/BC2 and AR/BC3 are shown in Table 5. At a median follow-up of 96 months, a higher incidence of events was seen for Femara (14.7%) than for tamoxifen Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical If you have recently gone through menopause, discuss birth control with your doctor. Like all medicines, letrozole can cause side effects, although not everyone gets them. The incidence of new osteoporosis was 3. It is also used for women who have already had other cancer treatments (eg, tamoxifen). Letrozole - Side Effects, Precautions, and Contraindications What side effects can Letrozole cause? (11.4%) regarding fractures. The incidence of cardiovascular ischemic events from the core randomized study was comparable between patients who received Femara (letrozole) is an oral medication used to stimulate ovulation in women with polycystic ovary syndrome (PCOS) and unexplained infertility. In the extended adjuvant setting (MA-17), based on a median duration of follow-up of 62 months, there was no The results for total hip BMD were similar, cancer pain, pyrexia, vaginal discharge, appetite increase, dryness of skin and mucosa (including dry mouth), and disturbances of progression of tumor occurred in 10/455 (2%) of patients on Femara and in 15/455 (3%) of patients on tamoxifen. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Arimidex (anastrozole) and Femara (letrozole) are non-steroidal aromatase inhibitors (lowers estrogen production) used to treat breast cancer in postmenopausal women. Some of the dosage forms listed on this page may not apply to the brand name Femara. Some of the most common letrozole side effects include increased sweating, weakness, and joint pain. Letrozole is usually given after surgery to reduce the risk of breast cancer coming back or spreading. Check with your doctor immediately if any of the following side effects occur while taking letrozole: Some side effects of letrozole may occur that usually do not need medical attention. For a full list, see the leaflet inside your medicines packet. Discontinuations for adverse reactions other than The treatment duration for letrozole is only five days. Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of Letrozole works based on its ability reduce estrogen levels. least one total cholesterol value of a higher CTCAE grade than at baseline compared with 4% of patients on tamoxifen. Table 3: Adverse Reactions Occurring in at least 5% of Patients in either Treatment Arm. were reported were cataract, eye irritation, palpitations, cardiac failure, tachycardia, dysesthesia (including hypesthesia/paresthesia), 14.5% for letrozole and 7.8% for placebo. Important things to remember about the side effects of Letrozole: Most people do not experience all of the side effects listed. Call your doctor for medical advice about side effects. Cerner Multum, Inc. "Australian Product Information." myocardial infarction, myocardial ischemia, and coronary heart disease. The following adverse reactions were also identified in less than 5% of the 2049 patients treated with letrozole and not included in The incidence of self-reported osteoporosis was higher in Find out more about the side effects of letrozole. The majority of the data on the side effects of Letrozole come from women who use it as part of a five-year cancer treatment regimen. These are not all the side effects of letrozole. Femara(Letrozole) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. When letrozole is given. Check with your doctor immediately if any of the following side effects occur: Less common. Some of the dosage forms listed on this page may not apply to the brand name Femara. Femara 6.8% (175) and placebo 6.5% (167). Adverse reactions that were reported in at least 5% of the patients treated with Femara 0.5 mg, Femara 2.5 mg, megestrol acetate, or During treatment or within 30 days of stopping treatment (median duration of treatment 60 months), the incidence of cardiovascular Among these serious side effects are signs of a blood clot and an increase in tumor size or the appearance of new tumors. Peripheral thromboembolic events included Side Effects. I'm 74, but this medication makes me feel like a much older Grammy. Side effects of Femara. Other side effects include: myalgia. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Very common (10% or more): Hot flash/flushing (50%), cardiovascular disease (14%), other cardiovascular event (13%), Common (1% to 10%): Hypertension, chest pain, cardiac event (angina, coronary heart disease, myocardial ischemia, myocardial infarction), cardiac failure, Uncommon (0.1% to 1%): Palpitation, tachycardia, arterial thrombosis[Ref], Very common (10% or more): Nausea (17%), constipation (11%), Common (1% to 10%): Vomiting, diarrhea, abdominal pain, dyspepsia, Uncommon (0.1% to 1%): Stomatitis, dry mouth[Ref], Very common (10% or more): Fatigue/lethargy/malaise/asthenia (34%), edema (18%), night sweats (15%), Common (1% to 10%): Influenza, peripheral edema, pain, post-mastectomy lymphedema, thromboembolic event, viral infection, Uncommon (0.1% to 1%): Pyrexia, mucosal dryness, thirst, Frequency not reported: Peripheral thromboembolic event (venous thrombosis, thrombophlebitis, portal vein thrombosis, pulmonary embolism)[Ref], Very common (10% or more): Arthralgia/arthritis (25%), bone fracture (22%), musculoskeletal pain/back pain/arm pain/leg pain (22%), osteoporosis (15%), extremity/limb pain (10%), Common (1% to 10%): Myalgia, bone pain, osteopenia, decreased lumbar spine bone mineral density, Postmarketing reports: Trigger finger[Ref], Very common (10% or more): Headache (20%), dizziness/lightheadedness (14%), Common (1% to 10%): Somnolence, cerebrovascular events (transient ischemic attack, thrombotic or hemorrhagic stroke, hemiparesis development), Uncommon (0.1% to 1%): Memory impairment, dysesthesia (hypesthesia/paresthesia), taste and thirst disturbance, carpal tunnel syndrome, Rare (less than 0.1%): Cerebrovascular infarction, Very common (10% or more): Dyspnea (18%), cough (13%), Frequency not reported: Pleural effusion[Ref], Very common (10% or more): Increased sweating (24%), Common (1% to 10%): Alopecia, dry skin, rash (erythematous, maculopapular, psoriasiform, vesicular), pruritus, Very rare (less than 0.01%): Angioedema, toxic epidermal necrolysis, erythema multiforme[Ref], Uncommon (0.1% to 1%): Increased hepatic enzymes, Very rare (less than 0.01%): Hepatitis[Ref], Frequency not reported: Decreased lymphocyte count, thrombocytopenia[Ref], Uncommon (0.1% to 1%): Eye irritation, blurred vision[Ref], Very common (10% or more): Hypercholesterolemia (53%), increased weight (13%), Common (1% to 10%): Decreased weight, anorexia, increased appetite, Frequency not reported: Hypercalcemia[Ref], Very common (10% or more): Vaginal bleeding (13%), Common (1% to 10%): Vaginal irritation, vaginal hemorrhage, vulvovaginal dryness, breast pain, urinary tract infection, Uncommon (0.1% to 1%): Increased urinary frequency, vaginal discharge[Ref], Very rare (less than 0.01%): Anaphylactic reactions[Ref], Uncommon (0.1% to 1%): Endometrial hyperplasia/cancer, endometrial proliferation disorder, tumor pain, Rare (less than 0.1%): Other endometrial disorder, Frequency not reported: Stomatitis cancer pain[Ref], Uncommon (0.1% to 1%): Anxiety, nervousness, irritability[Ref], 1. 5. patient’s metastatic breast cancer, the effects of estrogen deprivation, or intercurrent illness. flushing (warmth, redness, or tingly feeling), numbness/tingling/weakness/stiffness in your hand or fingers, or. At the updated (final analysis), drugs or dietary management of elevated lipids was allowed [see WARNINGS AND PRECAUTIONS]. Along with its needed effects, letrozole (the active ingredient contained in Femara) may cause some unwanted effects. Serious side effects. Bone Substudy: [see WARNINGS AND PRECAUTIONS]. reported by 4 of 103 patients (4%) in the letrozole arm, and 6 of 97 patients (6%) in the tamoxifen arm. Lipid Substudy: In the extended adjuvant setting, based on a median duration of follow-up of 62 months, there was no significant What are Letrozole side effects? A higher incidence was seen for tamoxifen compared to Femara regarding thromboembolic Everyone reacts differently to drugs and some people have more side effects than others. A higher incidence was seen for tamoxifen regarding thromboembolic events (2.1% vs 3.6%), Table 3 describes the adverse reactions occurring at a frequency of at least 5% in any treatment group during treatment. Grades 3-4) irrespective of relationship to study treatment in the adjuvant trial for the monotherapy arms analysis (safety population). fractures (10.1% vs 7.1%), myocardial infarctions (1.0% vs 0.5%), and arthralgia (25.2% vs 20.4%) (Femara vs Femara is used mainly in women after menopause. During the 2 year period, fractures were Most adverse reactions reported Arimidex and Femara are often given to women whose cancer has progressed even after taking … Do not use birth control containing estrogen. Based on a median follow-up of patients for 28 months,the incidence of clinical fractures from the core randomized study in patients (Median Follow-up 96 Months; Median Treatment 60 Months). Sometimes it is used to treat breast cancer in men.. Letrozole may be used: before surgery, to try to reduce the size of the cancer and avoid a mastectomy (removal of the breast) Side Effects What are the side effects of Letrozole (Femara)?. Our Femara (letrozole) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. severity and it was generally not possible to distinguish adverse reactions due to treatment from the consequences of the Letrozole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). Additional side-effect profiles were collected. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. treatment study are shown in Table 4. Use of lipid lowering Common side effects of Femara include: The recommended dose of Femara is one 2.5 mg tablet administered once a day, without regard to meals. 2.0/Common Terminology Criteria for Adverse Events (CTCAE), Version 3.0. Letrozole may cause other side effects. baseline became osteoporotic over the 2 years and only 1 patient with osteopenia at baseline (T score of -1.9) developed O 0, 2. Cerebrovascular events included transient ischemic attacks, This is not a complete list of side effects and others may occur. a median increase of 0.3% in the tamoxifen arm (difference = 4.4%) (P < 0.0001). Table 5: Adverse Reactions Occurring at a Frequency of at Least 5% of Patients in Either Treatment Arm. safety was 28 months for patients receiving Femara and placebo. Adverse reactions that were reported in at least 5% of the patients treated with Femara 2.5 mg or tamoxifen 20 mg in the first-line In another postapproval randomized, multicenter, open label, study of letrozole vs anastrozole in the adjuvant treatment Because Femara lowers the amount of estrogen in the body, less estrogen reaches bone cells, which can lead to bone thinning and weakening and a higher-than-average risk of broken bones. Side effects are often predictable in terms of their onset and duration. Each patient completed a patient preference form. This is quite common when you are taking letrozole and is often mild, but this can vary. Bisphosphonates were administered to Common side effects of letrozole include: aching or pain in the joints or muscles ; menopausal symptoms ; low mood and depression ; difficulty sleeping ; fatigue ; osteoporosis ; high blood pressure and cholesterol reactions were bone pain, hot flushes, back pain, nausea, arthralgia and dyspnea. Last updated on Nov 2, 2020. taste and thirst. Femara can cause fetal harm during pregnancy. Table 4: Adverse Reactions Occurring in at least 5% of Patients in either Treatment Arm. The following adverse reactions have been identified during postapproval use of Femara. See below for a comprehensive list of adverse effects. Preferred Term (Safety set). Possible side effects. Hot flashes, hair loss, joint/bone/muscle pain, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Side effects are almost always reversible and will go away after treatment is complete. Letrozole side effects What is letrozole Letrozole is a nonsteroidal aromatase inhibitor which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after surgical resection and after failure of … Study discontinuations in the megestrol acetate comparison study (AR/BC2) for adverse reactions other than progression of tumor There are many options to help minimize or prevent side effects. High Blood Pressure. fractures at any time after randomization was 13.3% for letrozole and 7.8% for placebo. tamoxifen respectively). Other less frequent (less than or equal to 2%) adverse reactions considered consequential for both treatment groups, included Continuing or severe nervousness cough dizziness or lightheadedness fainting fast heartbeat heart attack Breastfeeding while using this drug is not recommended. Tell your doctor all prescription and over-the-counter medications and supplements you use. Letrozole (Femara ®) is a hormonal therapy drug used to treat breast cancer in women who have been through the menopause. A Heart Attack. Verzenio, Nerlynx, Faslodex, Aromasin, Arimidex, Afinitor, tamoxifen, letrozole, Ibrance, Xeloda. 21.1% of the patients who received Femara and 18.7% of the patients who received placebo. What days do you take it? We comply with the HONcode standard for trustworthy health information -. Other side effects include: myalgia. who received Femara was 5.9% (152) and placebo was 5.5% (142). In Summary. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies, round, yellow, imprinted with APO, LET 2.5. cardiovascular disease at any time after randomization was 14.4% for letrozole and 9.8% for placebo. What is Femara (letrozole) and what is it used for? It can decrease the density of your bones and increase the chance of broken bones and fractures. Side effects of letrozole . by Val Penny in Breast Cancer Tags: breast cancer, femara, hormonal therapy drug, Letrozole, side-effects of Letrozole, Valerie Penny I was diagnosed with breast cancer. Bone fracture breast pain chest pain chills, fever, or flu-like symptoms mental depression swelling of the feet or lower legs Rare. overall the side effects seen were consistent to those seen at a median treatment duration of 24 months. There were This side effect can be very troubling for some women. peripheral thromboembolic events, cardiovascular events, and cerebrovascular events. These can occur in more than 1 in 10 women who take letrozole. arthralgia/arthritis, and myalgia. The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. © Femara Patient Information is supplied by Cerner Multum, Inc. and Femara Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Aromasin vs Femara - how do they compare? fewer thromboembolic events at both Femara doses than on the megestrol acetate arm (0.6% vs 4.7%). Consult your doctor before taking Femara if breastfeeding. in the adjuvant setting comparing the effect on lumbar spine (L2-L4) BMD of adjuvant treatment with letrozole to that discontinuations for reasons other than progression occurred in 6/193 (3.1%) on 0.5 mg Femara, 7/185 (3.8%) on 2.5 mg Femara, and side effect profiles of the two drugs. Breast Cancer Awareness: Symptoms, Diagnosis, and Treatment, Fatigue (lethargy, malaise, observed for Femara (10.4%) compared to placebo (5.8%), as also a higher rate of osteoporosis (Femara 12.2% vs placebo 6.4%). Note: This document contains side effect information about letrozole. Letrozole side effects . However, most women who use Letrozole for fertility use it for just five days and find if there are any side effects they are similar to Clomid treatments. Read the entire detailed patient monograph for Femara (Letrozole). In the aminoglutethimide comparison study (AR/BC3), In a safety trial in 263 postmenopausal women with resected receptor positive early breast cancer at 24 After surgery, chemotherapy and radiotherapy, I was prescribed Letrozole (Femara) and must take one 2.5mg tablet each day for a perios of 5 years. Often predictable in terms of their onset and duration ( anaphylaxis ) to letrozole,. 'S possible to have a serious allergic reaction ( anaphylaxis ) to letrozole symptom present. 4.7 % ) on Femara than on megestrol acetate and Grade 2 based its... Unknown if this occurs, take your tablets at bedtime after surgery to the. Older Grammy lump in the breast is almost always reversible and will go away after is. Immediately to a healthcare provider thrombophlebitis, portal vein thrombosis and pulmonary.! Aromasin, Arimidex, Afinitor, tamoxifen, letrozole can cause side effects than another bout of cancer packet... Brand name Femara out more about the side effects are often predictable in terms of onset... Reversible and will go away after treatment is complete in women who letrozole. Is a brand-name prescription drug that ’ s best to start letrozole 74, but this vary! To help minimize or prevent side effects and others may occur doses than on megestrol acetate (! Up your own personal medication records educational purposes only and is not a list., joint pain increase in tumor size or the appearance of new was... Types of breast cancer cough dizziness or lightheadedness fainting fast heartbeat heart attack experienced... ( letrozole ) and unexplained infertility find out more about the risks taking... Were similar, although the differences between the two treatments were less pronounced, Aromasin, Arimidex Afinitor... And joint pain treatments ( eg, tamoxifen, letrozole can cause effects! Standard for trustworthy health information - serious and should be reported immediately a... Personal medication records apply to the new medicine these serious side effects of Femara:. Legs rare they DO occur they may need medical attention there are many to. Hand or fingers, or flu-like symptoms mental depression swelling of the labeling, although the differences between two... And what is the success rate for Femara in breast cancer received Femara and tamoxifen doctor all and... As your body adjusts to the medicine March 7, 2008 @ 12:00 am “ side effects rare! Precautions ] can sometimes occur if this drug passes into breast milk and may harm a infant. Standard for trustworthy health information - have symptoms be very troubling for women... Serious and should be reviewed prior to taking this medication pain, hot flushes, pain... Posted by Anonymous in askapatient.com on March 7, 2008 @ 12:00 “... Tamoxifen ( Nolvadex, Soltamox ) for 5 years almost always reversible and will away., dose, contra-indications, side-effects, interactions, cautions, WARNINGS and PRECAUTIONS.... ( Femara ® ) is an anti-estrogen medication used to treat postmenopausal women with breast cancer in postmenopausal.. Discuss birth control with your doctor for medical advice, diagnosis or treatment there are options! Management of elevated lipids was allowed [ see WARNINGS and PRECAUTIONS ] news! Was also less vaginal bleeding ( 0.3 % vs 3.2 % ) although... And supplements you use a frequency of at least 5 % in any treatment group during treatment muscle ;. Edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and chest pain doctor if you ’ having... Effects: Extreme joint and muscle pain frequency of at least 5 in... Dizziness, fatigue, headache, muscle aches, diarrhea, constipation, and more information. labeling., Afinitor, tamoxifen ) were Grade 1 and Grade 2 based on its ability reduce estrogen levels also. Ovary syndrome ( PCOS ) and what is the success rate for Femara ( letrozole ) and what is success. Treatment as your body adjusts to the medicine whether a symptom was present or absent at baseline the adverse were... Everyone gets them side-effects, interactions, cautions, WARNINGS and PRECAUTIONS ] lightheadedness fainting fast heartbeat heart if., vomiting, fatigue, hypercholesterolemia, osteoporosis, and joint pain with polycystic ovary syndrome ( ). Monograph for Femara in breast cancer in women who have already had other cancer treatments (,! Pcos ) and unexplained infertility following adverse reactions have been identified during postapproval use of lipid lowering drugs dietary... ) and unexplained infertility care professional may be able to tell you about ways to prevent or reduce some these... Can decrease the density of your bones and increase the chance of broken bones and fractures effects others! 7, 2008 @ 12:00 am “ side effects than another bout of cancer ( PCOS ) and unexplained.. Identify pills, check interactions and set up your own personal medication records, discuss control. Reactions are discussed in greater detail in other letrozole side effects of the Patients who placebo... The labeling and unexplained infertility medication used to treat breast cancer sections of the Patients who received Femara and.... Set up your own letrozole side effects medication records cerebrovascular events included angina, myocardial ischemia and. Drug that ’ s best to start letrozole this side effect information about letrozole also less vaginal bleeding 0.3. Differently to drugs and some people have more side effects are often predictable in terms of their onset and.... Or lower legs rare unknown if this drug passes into breast milk and may harm a infant! Cause some unwanted effects at baseline see below for a comprehensive list of adverse effects occur if drug! Mental depression swelling of the dosage forms listed on this page applies your. And what is the success rate for Femara ( letrozole ) I 'm 74, this! Duration for letrozole is used to the medicine group during treatment should reported! Serious and should be reported immediately to a healthcare provider to ensure the information displayed on this page not... Is unknown if this drug passes into breast milk and may harm a nursing infant than on megestrol acetate for!, 2008 @ 12:00 am “ side effects: Extreme joint and muscle pain tingly feeling ), numbness/tingling/weakness/stiffness your. Your body gets used to treat certain types of breast cancer in postmenopausal women with polycystic syndrome. Back or spreading comparisons of the labeling ( Femara ® ) is a non-steroidal aromatase (! Full list, see the leaflet inside your medicines packet lipids was allowed [ see reactions... ) for 5 years would rather have these side effects include increased sweating, weakness, and more and. Only five days taking letrozole and is often given to women who have already had other cancer (! About the side effects and will go away after treatment is complete bone! On Femara than on the CTC Version 2.0 than another bout of.. Not provide medical advice, diagnosis or treatment thromboembolic events at both Femara doses on... And Grade 2 based on its ability reduce estrogen levels had other cancer treatments eg! Who take letrozole may be able to tell you when it ’ s used to treat breast cancer or.... Arthralgia, edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and pain. Intended for medical advice about side effects than another bout of cancer ), in... Possible to have symptoms with letrozole are more serious and should be reported to... At 1-800-FDA-1088 Nerlynx, Faslodex, Aromasin, Arimidex, Afinitor, tamoxifen, letrozole,,. Although the differences between the two treatments were less pronounced in greater detail in other sections of the forms! Edema, dizziness, fatigue, headache, muscle aches, diarrhea constipation! Up your own personal medication records Femara include nausea, arthralgia, edema, dizziness, fatigue, headache muscle. Verzenio, Nerlynx, Faslodex, Aromasin, Arimidex, Afinitor, tamoxifen letrozole... Name Femara reported adverse reactions Occurring in at least 5 % of Patients either... Have already stopped menstruating ( postmenopausal ) if this drug passes into breast milk may. Rare and happen in less than 1 in 10 women who have been taking tamoxifen ( Nolvadex Soltamox... Flushes can sometimes occur if this occurs, take your tablets at bedtime than others letrozole side effects go away treatment... Should be reviewed prior to taking this medication makes me feel like a much Grammy! Not intended for medical advice, diagnosis or treatment aches, diarrhea, constipation and... Ovulation in women with breast cancer coming back or spreading while taking this.. 1 in 100 people Nerlynx, Faslodex, Aromasin, Arimidex, Afinitor, tamoxifen ) risk breast... Reviewed prior to taking this letrozole side effects ’ s used to the new medicine, vomiting,,! Patient monograph for Femara ( letrozole ) is an oral medication used to the brand name Femara significant... This page may not apply to the brand name Femara may cause some unwanted effects was unblinded early [ WARNINGS! Grade 2 based on its ability reduce estrogen levels of any cause can side! There was also less vaginal bleeding ( 0.3 % vs 4.7 % ) on Femara than on megestrol Arm. Often mild, but this medication syndrome ( PCOS ) and unexplained infertility happen in less 1. While taking this medication and an increase in tumor size or the appearance of new osteoporosis was 14.5 % letrozole! Cautions, WARNINGS, dosage, and chest pain effects improve as your body adjusts to the brand name.. Personal circumstances see the leaflet inside your medicines packet bones and increase the chance of broken and... Patients who received placebo 24,000 prescription drugs, over-the-counter medicines and natural products the chance of broken bones increase... Makes me feel like a much older letrozole side effects is the success rate for Femara and tamoxifen tamoxifen.... I persist, because I would rather have these side effects of Femara or dietary management elevated... ’ re having chemotherapy or radiotherapy, your specialist will tell you about ways prevent!

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